Aeras, GSK deal to Advance TB Vaccine research

Posted on | oktober 11, 2012 | No Comments

War against tuberculosis has gone a notch higher following an agreement between Aeras and GlaxoSmithKline Vaccines, S.A. (GSK) to provide resources to run a multi-center proof of concept clinical trial to test a vaccine candidate in healthy adults between 18 and 50 years of age in Kenya, South Africa and India beginning next year pending approvals from authorities.

The new agreement comes after promising results from early stage clinical trials showed that the GSK TB vaccine candidate known as M72/AS01E* has an acceptable safety and reactogenicity profile and demonstrated an immune response.

This novel research and resource-sharing agreement between the largest non-profit TB vaccine biotech and one of the world’s leading research-based pharmaceutical and healthcare companies marks advancement in the race to develop new vaccines against TB, a global infectious disease killer.

“This partnership signals our commitment to building innovative collaborations to develop and deliver new TB vaccines,” said Jim Connolly, President and Chief Executive Officer of Aeras. “We will never reverse the spread of the global TB epidemic without new vaccines as part of the solution.”

“When considering the massive public health impact and costs to society of neglected diseases including tuberculosis, global financing for R&D remains critically low in this area,” said Jim Connolly.

“Working in partnership with GSK – sharing resources, capabilities and know-how – affords us the opportunity to conduct this pivotal, multi-country proof of concept trial, getting us that much closer to potentially one day having a TB vaccine that could protect adolescents and adults from one of the world’s deadliest infectious diseases.”

TB continues to kill 1.4 million men, women and children annually, despite the widespread use of the currently available TB vaccine, Bacille Calmette-Guèrin (BCG), in TB endemic countries. BCG prevents some forms of TB in infants but does not prevent pulmonary TB, which accounts for the majority of infections and deaths among adolescents and adults.

The GSK vaccine candidate developed under this new agreement is being designed to be used in addition to BCG.

AUTHOR: Henry Neondo
URL: http:// www.africasciencenews.org
E-MAIL: neondohenry [at] yahoo.com

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